Description
By Vahid Mansouri and Maryam Bemanalizadeh.
Gene Therapy in Neurodegenerative Disorders: From Bench to Bedside offers a comprehensive review of gene therapy modalities and their applications in treating neurodegenerative disorders. The initial chapters cover the fundamentals of gene therapy strategies, including gene delivery methods and CNS-targeted delivery. Subsequent chapters delve into specific neurodegenerative disorders such as Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), and Alzheimer’s Disease (AD), highlighting the latest gene therapy approaches for each condition. Each chapter provides a detailed introduction to the relevant field before exploring specific tools and applications. With contributions from leading experts, the book addresses current and ongoing clinical trials, potential challenges, and promising advances in gene therapy for neurodegenerative disorders. It also discusses regulatory and ethical considerations in translating research from bench to bedside. This book is an essential resource for basic science researchers in gene therapy, geneticists, biotechnologists, and clinical researchers seeking new and effective treatments for neurodegenerative diseases. It equips readers with the knowledge and tools needed to advance their work and drive innovation in gene therapy.
- Provides a comprehensive understanding of gene therapy in neurodegenerative disorders
- Details novel gene therapy modalities
- Covers potential challenges and promising advances in gene therapy strategies
- Explores specific gene delivery methods and their applications in various neurodegenerative diseases
- Highlights current and ongoing clinical trials and their implications for future research
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