Molecular Basis of Oxidative Stress: Chemistry, Toxicology, Disease Pathogenesis, Diagnosis, and Therapeutics (2nd Edition)

Description

PDF: 19.7MB

By: Frederick A. Villamena, Henry Jay Forman

In-depth resource on mechanisms of oxidative stress and damage and the role of free radicals in disease, diagnosis, and therapeutics Molecular Basis of Oxidative Stress is a comprehensive resource on the molecular and chemical bases of oxidative stress, providing insight on various diseases caused by oxidative stress (cancer, cardiovascular, neurodegenerative) and the role of reactive oxygen species (ROS) in disease pathogenesis along with in-depth knowledge about the mechanisms of oxidative stress and damage, free radical chemistry, and the role of free radicals in disease, diagnosis, and therapeutics. Thoroughly updated and expanded to reflect advances since its original publication, the Second Edition includes new chapters on oxidative stress mechanisms, biomarkers, and therapeutic strategies for the management and treatment of diseases. The disease section features 10 new emerging diseases, including kidney and eye diseases and COPD.

This Second Edition also covers developments in the field over the last several years, such as increases in mortality rates from air pollution and from obstructive pulmonary diseases in which exogenous oxidants are initiators. Written by a team of highly qualified academics, Molecular Basis of Oxidative Stress discusses sample topics including: Classification, physico-chemical properties, sources, and detection of reactive species and etiology of COPD from cigarette smoke and pollution Oxidative, reductive and indirect non-redox modifications of key biomolecular systems such as lipids, proteins, and DNA by reactive species Gene expression of antioxidant defense enzymes, mitochondrial dysfunction and aberrant activation of NOX and cell signaling Biomarkers of oxidative stress in neurodegenerative diseases and emerging fields inbiomarker discovery such as cysteinylated albumin and nitroalkene fatty acids Imparting strong foundational knowledge of redox chemistry, chemistry of oxidative damage and mechanisms of oxidative stress, and oxidative stress-mediated disease pathogenesis, Molecular Basis of Oxidative Stress is an essential reference for both novice and advanced toxicologists, biochemists, and pharmacologists, along with clinical and medical scientists in various fields such as oncology, cardiovascular, andneuroscience.

PDF Preview